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Ophiucus III was one of two Class M planets in the Ophiucus system, the other being Ophiucus VI. Though the planet had no native fauna, it had extensive plant life. The Federation established an agricultural colony there circa 2212. (TOS comic: Leonard McCoy, Frontier Doctor)

The planet was still considered a frontier world in the 2260s, when Harry Mudd planned to transport wives to settlers there. (TOS: "Mudd's Women")

By the 2290s, the city of New Dakar had been established on the planet, and was known for its artist's community. (TOS novel: The Fire and the Rose)

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