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The Azure Nebula was a class 11 nebula on the border of the United Federation of Planets and the Klingon Empire in the Beta Quadrant. It was composed primarily of oxygen and argon, with smaller amounts of theta-xenon, flourine and sirillium. (VOY: "Flashback")

The Nebula spanned several lightyears and occupied portions of the Azure, Carraya, H'atoria, Mempa and Nimbus sectors, adjacent to the Triangle region. In the 2380s, a network of subspace tunnels was discovered within the nebula, leading to multiple points across the Milky Way. At that time, Starbase 234 was the closest Starfleet base to the nebula. (Star Trek: Star Charts; Star Trek: Destiny)

Circa 2409, the Tholian Assembly began using the subspace tunnels to invade the adjacent sectors, in pursuit of Iconian artifacts. (Star Trek Online)

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