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The Alpha Jem'Hadar, or Alphas for short, were a subset of Jem'Hadar created in Alpha Quadrant during the Dominion War. The Dominion bred them to specifically combat the species of the Alpha and Beta Quadrants, while they were unable to receive reinforcements through the Bajoran wormhole from the Gamma Quadrant. The Alphas viewed themselves as superior to their Gamma Quadrant-bred brethren. (DS9: "One Little Ship")

After the Dominion War ended in 2375, most of the Alphas refused to return to the Gamma Quadrant with the rest of the Dominion forces. Ten years later, in 2385, Odo extended an invitation to the Alphas to come home to the Dominion, but was rejected.

In 2386, the Alphas, led by First Lamat'Ukan took control of the planet Devos II, and built a ketracel-white production facility there. They made no further movement from the planet. (Star Trek Online: The Path to 2409)

In the early 2400s, the True Way began courting an alliance with the Alpha Jem'Hadar. (Star Trek Online: Cardassian Struggle)

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